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Bovine papilloma and fibropapilloma are among the benign neoplastic changes observed in cattle (1). Notably, several types of papillomavirus have been implicated in the etiology of viral-induced papillomas (2), including bovine papillomaviruses (BPVs) -1 to -6 (5). More recently, the family Papillomaviridae has been expanded to include 13 members (BPV-1 to -13), and BPV infection has been found to not only affect cattle but also humans and several other domestic and wild animal species (24, 25). Papilloma and/or fibropapilloma are characterized by progressive and regressive phases. The progressive phase almost always follows the regressive phase in immunocompetent animals, mounting an immune response to BPV-1 infection, during which mononuclear cells, lymphocytes, and macrophages are activated to protect host cells from the virus (6). The progressive phase is characterized by hyperplastic stratum spinosum and acanthosis, hyperkeratosis, apoptosis, and occasional inflammatory reactions; Investigation of E2, E5, and E6 gene expression and DNA in situ fragmentation findings associated with progressive and regressive changes in benign neoplastic cutaneous lesions arising naturally from bovine papillomavirus-1 infection

medycyna weterynaryjna

Investigation of E2, E5, and E6 gene expression and DNA in situ fragmentation findings associated with progressive and regressive changes in benign neoplastic cutaneous lesions arising naturally from bovine papillomavirus-1 infection