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The spread of rabies virus between adjacent mouse neuroblastoma cells was inhibited in the presence of spleen cells from mice sensitized to rabies virus as measured by the size of fluorescent focus formation. This activity of focus size reduction was appeared to be closely related to the deVelopment of cell-mediated cytotoxic activity. Rabies virus inactivated by beta-propiolactone was also capable of generating such an activity as

FLUORESCENT FOCUS SIZE REDUCTION BY SPLEEN CELLS OF MICE IMMUNIZED WITH RABIES VIRUS