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The inhibition titers of sera from adult residents in Dar es Salaam, Tanzania to intraerythrocytic growth of Plasmodium falciparum were not correlated to their antibody titers by immunofluorescence and enzyme immunoassay, and did not exhibit specificity to the strain with a certain MSA-1 gene. Another inhibitory factor (s) was found in a low molecular fraction with molecular weight less than 30, 000 that was separated from a high molecular fraction by centrifugation on a membrane filter (centriprep-30, Amicon) This factor induced morphological changes of intraerythrocytic parasites and was thought to correspond to crisis form factor (CFF) by Jensen et al. (1982). The factor was shown to remain in the serum of an adult Tanzanian who had lived in a non-malarious area six months prior to the commencement of this study and to be contained in a hyperimmune serum from a Japanese patient even though on a low level.

Growth inhibition of cultured Plasmodium falciparum by immune serum from Tanzania.