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The incidence of postoperative nausea and vomiting (PONV) after middle ear surgery is high. In this study we want to compare the effects of intravenous Granisetron and oral gabapentin as a premedication before surgery in patients undergoing middle ear surgeries. MATERIALS AND METHODS: We enrolled 60 patients that were randomly divided into the two groups of 30 in each. Group I received Granisetron 3 mg iv 2 minutes before induction of anesthesia; Group II received oral Gabapentin 300 mg 1 hour before induction. The incidence and severity of PONV were recorded each 30 minutes for 1st 6 hours in the post-anesthesia care unit (PACU) and each 2nd hourly 10 hours and 4th hourly for next 8 hours. The severity of nausea was assessed by visual analogue scale (VAS). RESULT: The incidence and severity of nausea and vomiting at different time intervals in Groups I and Group II was not significant. There was no significant difference in the incidence of side effects like respiratory depression, apnea, extra pyramidal disorders, drowsiness, dizziness, vertigo and headache in two groups. CONCLUSION: The study was shown that using Gabapentin and Granisetron have equal anti-emetic effects, These submit the efficiency of these drugs in preventing Post operative nausea and vomiting (PONV).

international journal of advanced research

A PROSPECTIVE, RANDOMIZED STUDY COMPARING THE ANTIEMETIC EFFECT OF INTRAVENOUS GRANISETRON AND ORAL GABAPENTIN IN PREVENTING POSTOPERATIVE NAUSEA AND VOMITING AFTER MIDDLE EAR SURGERY IN ADULT.