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TBM is one of the most common causes of sub-acute lymphocytic meningitis in the developing countries. In developing countries, TB meningitis is still a disease of childhood with the high incidence in the first three years of life (Tandon PN, Brattier R, Handbook of clinical neurology, Donald PR). Tuberculous meningitis (TBM) can occur as the sole manifestation of Tuberculosis. (1-3) Delays in seeking medical care, diagnosis, and initiation of treatment are contributing factors to the high mortality and morbidity, especially in resource-limited regions. When diagnosed promptly, TBM can be cured with supervised medication administration and supportive care. Even after many years of experience with the disease, the definitive diagnosis of TBM remains a problem. Early diagnosis and treatment of TBM is necessary because in the untreated patients the mortality is 100% in 5 to 8 weeks (Molavi and Le Frock 1985). The definitive diagnosis can be done by isolating the tubercle bacilli from the CSF, the conventional diagnostic modalities like microscopy and culture lack sensitivity and are time-consuming and most often culture is negative in paucibacillary conditions. The nucleic acid amplification technique (NAA), notably the polymerase chain reaction (PCR) has revolutionized the investigative microbiology by facilitating direct detection and identification of infectious agent in the clinical samples in a very short time. Sensitivities vary from 33% to 90%, specificities from 88% to 100%.

TB-PCR, UTILITY IN PRESENT SCENARIO - STUDY FROM TERTIARY CARE CENTER IN NORTHERN INDIA.