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SCN1A (3184 A &gt; G) and SCN2A (56G &gt; A) gene encodes α subunit of the neuronal voltage-gated sodium channel, which is a target for carbamazepine (CBZ). Recent studies have demonstrated that polymorphism of SCN1A (3184 A &gt; G) and SCN2A (56G &gt; A) was associated with use of CBZ. However, it has not been determined whether the polymorphism affects CBZ or other antiepileptic drug responsiveness. The aim of the study was to establish whether the SCN1A (3184 A &gt; G) and SCN2A (56G &gt; A) polymorphisms of the SCN1A and SCN2A genes affect responsiveness to CBZ.

The possible effect of SCN1A and SCN2A genetic variants on carbamazepine response among Khyber Pakhtunkhwa epileptic patients, Pakistan