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Alcoholic cirrhosis represents 1% of all cause-of-deaths worldwide. Its incidence is higher in males and results from the combination of environmental and genetic factors. Among all the genetic determinants of alcoholic cirrhosis, the patatin-like phospholipase domain protein 3 ( PNPLA3 ) rs738409 represents the most widely validated determinant. Recent cross-sectional studies on alcohol abusers identified transmembrane-6 superfamily member 2 ( TM6SF2 ) rs58542926, membrane bound O-acyltransferase domain containing 7 ( MBOAT7 ) rs641738, and cluster of differentiation 14 ( CD14 ) rs2569190 as new genetic risk factors for alcoholic cirrhosis. We aimed to develop a gene-based risk score to predict the incidence of alcoholic cirrhosis in males with at-risk alcohol consumption.

A two gene-based risk score predicts alcoholic cirrhosis development in males with at-risk alcohol consumption