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α-Thalassemia, one of the major thalassemia types in Thailand, is caused by either deletion or non-deletional mutation of one or both α-globin genes. Inactivation of three α-globin genes causes hemoglobin H (Hb H) disease, and the combination of Hb H disease with heterozygous hemoglobin E (Hb E) results in AE Bart's disease.

Clinical and molecular genetic features of Hb H and AE Bart&rsquo;s diseases in central Thai children

Clinical and molecular genetic features of Hb H and AE Bart’s diseases in central Thai children