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Sperm-associated antigen 9 (SPAG9) is upregulated in several malignancies and its overexpression is positively correlated with cancer cell malignancies. However, the specific biological roles of SPAG9 in hepatocellular carcinoma (HCC) are less understood.

SPAG9 is involved in hepatocarcinoma cell migration and invasion via modulation of ELK1 expression