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Single-nucleotide polymorphisms in apoptosis-related genes have been shown to play a role in the efficacy of platinum-based chemotherapy and may influence clinical outcomes. Our study aimed to evaluate the correlations of four functional single-nucleotide polymorphisms - FAS -670 A&gt;G, FAS ligand -844 T&gt;C, survivin -31 G&gt;C, and survivin 9386 C&gt;T - with drug response and clinical outcomes in advanced non-small-cell lung cancer patients who received platinum-based chemotherapy.

oncotargets and therapy

Prognostic role of apoptosis-related gene functional variants in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy