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Hypoxia is a common phenomenon encountered in solid cancers, leading to chemotherapy resistance and therefore to aggressiveness of the disease. The homeostatic response to hypoxia is mediated by hypoxiainducible factor-1 (HIF-1). The aim of this study was to investigate the impact of HIF1α in patients with primary epithelial ovarian cancer.

oncotargets and therapy

HIF1&amp;alpha; is an independent prognostic factor for overall survival in advanced primary epithelial ovarian cancer &amp;ndash; a study of the OVCAD Consortium