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Resistance to drug therapy, along with high rates of metastasis, contributes to the low survival rate in patients diagnosed with pancreatic cancer. An alternate treatment for human pancreatic cancer involving targeting of Neu1 sialidase with oseltamivir phosphate (Tamiflu®) was investigated in human pancreatic cancer (PANC1) cells with acquired resistance to cisplatin and gemcitabine. Its efficacy in overcoming the intrinsic resistance of the cell to chemotherapeutics and metastasis was evaluated.

oncotargets and therapy

Therapeutic targeting of Neu1 sialidase with oseltamivir phosphate (Tamiflu&amp;reg;) disables cancer cell survival in human pancreatic cancer with acquired chemoresistance