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Osteosarcoma (OS) is the most common bone cancer diagnosed in children and adolescents. Expression of APE1 is commonly increased in OS, and this is negatively correlated with a sensitivity to platinum and a favorable prognosis. However, the mechanism underlying high APE1 expression in OS is not fully understood.

<p>MicroRNA-765 sensitizes osteosarcoma cells to cisplatin via downregulating APE1 expression</p>