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Purpose: We aimed to investigate the expression dynamics of Aquaporin 1 ( AQP1 ) in cervical cancer and evaluate correlations among AQP1 levels and the clinicopathological features of patients with cervical cancer. Patients and methods:  AQP1 mRNA and protein levels in cervical cancer and adjacent normal tissues were evaluated by quantitative reverse-transcription PCR (qRT-PCR) and western blot. Immunohistochemistry (IHC) for AQP1 was performed with a tissue microarray of cervical cancer (containing 63 cases of squamous cell cervical cancers and 10 normal cervical tissues) to investigate clinicopathological outcomes. Cut-off scores for positive expression of AQP1 were determined by receiver operating characteristic analysis. The χ  2 test was used to analyze correlations among AQP1 expression and clinicopathological features of cervical cancer. Results: The expression of AQP1 was decreased in the majority of cervical cancer tissues by qRT-PCR and western blot analysis. Positive expression of AQP1 was observed in 100% (10/10) of normal cervical tissues and in 42.86% (27/63) of cervical cancer tissues by IHC analysis. The cut-off score for positive expression of AQP1 was determined to be 45% of cancer cells. Decreased expression of AQP1 was correlated with clinicopathological features including; poor pathological grade ( P =0.000), late International Federation of Gynecology and Obstetrics stage ( P =0.008), and positive lymph nodes ( P =0.002). Conclusion: These data suggest that decreased expression of AQP1 correlated with progressive features in patients with cervical cancer. AQP1 levels may serve as a potential biomarker for the diagnosis of cervical cancer.

<p>Decreased expression of aquaporin 1 correlates with clinicopathological features of patients with cervical cancer</p>