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CD4 + CD25 + regulatory T cells (Tregs), a crucial component of the infiltration of immune cells in tumor microenvironment, are associated with progression and metastasis of hepatocellular carcinoma (HCC).

oncotargets and therapy

CD4&lt;sup&gt;+&lt;/sup&gt; CD25&lt;sup&gt;+&lt;/sup&gt; regulatory T cells promote hepatocellular carcinoma invasion via TGF-&amp;beta;1-induced epithelial&amp;ndash;mesenchymal transition