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Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute to cancer progression. In our study, we aimed to investigate the expression and clinical pertinence of serine peptidase inhibitor, Kunitz type 1 antisense RNA1 ( SPINT1-AS1 ) in CRC.

oncotargets and therapy

Increased expression of antisense lncRNA &lt;em&gt;SPINT1-AS1&lt;/em&gt; predicts a poor prognosis in colorectal cancer and is negatively correlated with its sense transcript