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The aims of this study were to determine whether the quantitative HER2 gene amplification level is related to the key clinicopathological features that represent the aggressiveness of breast cancer (BC) and to determine whether the quantitative HER2 gene amplification level could predict the treatment response in the subset of HER2-positive patients who received neoadjuvant targeted therapy.

oncotargets and therapy

Clinical significance of quantitative &lt;em&gt;HER2&lt;/em&gt; gene amplification as related to its predictive value in breast cancer patients in neoadjuvant setting