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Nijmegen breakage syndrome 1 (NBS1) has a vital role in DNA double-strand break (DSB) repair, functioning as a sensor to identify and repair DNA damage and maintaining genomic stability by participating in the intra-S-phase checkpoint. Polymorphisms of NBS1 have been investigated in multiple cancers with variable results. To our best knowledge, no previous study has focused on the association between NBS1 single-nucleotide polymorphisms (SNPs) and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).

oncotargets and therapy

A non-synonymous polymorphism in &lt;em&gt;NBS1&lt;/em&gt; is associated with progression from chronic hepatitis B virus infection to hepatocellular carcinoma in a Chinese population