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Naloxone is viewed as a specific competitive opioid antagonist acting at the level of opioid receptors (μ, δ, and κ) with blended agonist-adversary or agonist action. The role of naloxone in tumor cell growth has been poorly studied in human cancer cell lines.

The effects of naloxone on human breast cancer progression: in vitro and in vivo studies on MDA.MB231 cells