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The aim of this case-control study was to assess whether PPARG and IGF2BP2 polymorphisms confer susceptibility to esophageal squamous-cell carcinoma (ESCC). A total of 507 patients pathologically confirmed for ESCC and 1,496 age-, sex-, and residence-matched healthy individuals were enrolled. The PPARG rs1801282 C&gt;G and rs3856806 C&gt;T and IGF2BP2 rs1470579 A&gt;C and rs4402960 G&gt;T polymorphisms were selected and genotyped by SNPscan genotyping assays. Multivariable logistic analysis suggested that the PPARG rs3856806 C&gt;T polymorphism might increase the risk of ESCC. In different stratified analyses, there were significant associations between PPARG rs3856806 C&gt;T and risk of ESCC in female, never-smoking, drinking, and never-drinking subgroups. In addition, we also found that PPARG rs1801282 C&gt;G increased ESCC risk in the never-smoking subgroup. There was significant difference in C rs1470579 G rs4402960 C rs1801282 C rs3856806 -haplotype distribution among ESCC cases and control subjects. In conclusion, our findings highlight that PPARG rs1801282 C&gt;G and rs3856806 C&gt;T polymorphisms are candidates for susceptibility to ESCC in the eastern Chinese Han population. The C rs1470579 G rs4402960 C rs1801282 C rs3856806 haplotype is associated with susceptibility to ESCC.

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The relationship between &lt;em&gt;IGF2BP2&lt;/em&gt; and &lt;em&gt;PPARG&lt;/em&gt; polymorphisms and susceptibility to esophageal squamous-cell carcinomas in the eastern Chinese Han population