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In a Phase I dose-finding study of metronomic daily oral vinorelbine in advanced non-small-cell lung cancer, a recommended dose was established for this therapeutic approach. In addition, this trial revealed promising efficacy data and an acceptable tolerability profile. The observed vinorelbine blood concentrations suggest continuous anti-angiogenic coverage.

Metronomic treatment of advanced non-small-cell lung cancer with daily oral vinorelbine &ndash; a Phase I trial

Metronomic treatment of advanced non-small-cell lung cancer with daily oral vinorelbine – a Phase I trial