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correspondence: Jun Iwamoto Institute for Integrated sports Medicine, Keio University school of Medicine, 35 shinanomachi, shinjuku-ku, Tokyo 160-8582, Japan Tel +81 3 3353 1211 Fax +81 3 3352 9467 email jiwamoto@a8.keio.jp Background and objective: The objective of the present study was to determine whether celecoxib, a cyclo-oxygenase-2 inhibitor, would delay bone healing in a rat femoral osteotomy model by examining bone histomorphometry parameters. Methods: Twenty-one 6-week-old female Sprague-Dawley rats underwent a unilateral osteotomy of the femoral diaphysis followed by intramedullary wire fixation; the rats were then divided into three groups: the vehicle administration group (control, n = 8), the vitamin K 2 administration (menatetrenone 30 mg/kg orally, five times a week) group (positive control, n = 5), and the celecoxib administration (4 mg/kg orally, five times a week) group (n = 8). After 6 weeks of treatment, the wires were removed, and a bone histomorphometric analysis was performed on the bone tissue inside the callus. The lamellar area relative to the bone area was significantly higher and the total area and woven area relative to the bone area were significantly lower in the vitamin K 2 group than in the vehicle group. However, none of the structural parameters, such as the callus and bone area relative to the total area, lamellar and woven areas relative to the bone area, or the formative and resorptive parameters such as osteoclast surface, number of osteoclasts, osteoblast surface, osteoid surface, eroded surface, and bone formation rate per bone surface differed significantly between the vehicle and celecoxib groups. Conclusion: The present study implies that celecoxib may not significantly delay bone healing in a rat femoral osteotomy model based on the results of a bone histomorphometric analysis.

Celecoxib does not significantly delay bone healing in a rat femoral osteotomy model: a bone histomorphometry study