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The objective of this analysis was to develop a nonlinear disease progression model, using an expanded set of covariates that captures the longitudinal Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB) scores. These were derived from the Alzheimer's Disease Neuroimaging Initiative ADNI-1 study, of 301 Alzheimer's disease and mild cognitive impairment patients who were followed for 2-3 years.

neuropsychiatric disease and treatment

Disease progression model for Clinical Dementia Rating&amp;ndash;Sum of Boxes in mild cognitive impairment and Alzheimer&amp;rsquo;s subjects from the Alzheimer&amp;rsquo;s Disease Neuroimaging Initiative