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We investigated the effects of rivastigmine (a cholinesterase inhibitor) and selegiline ((-)deprenyl, an irreversible inhibitor of monoamineoxidase-B), alone and in combination, on brain acetylcholinesterase (AChE), (Na(+), K(+))-, Mg(2+)-ATPase activities, total antioxidant status (TAS), and learning performance, after long-term drug administration in aged male rats. The possible relationship between the biochemical and behavioral parameters was evaluated.

neuropsychiatric disease and treatment

The effects of rivastigmine plus selegiline on brain acetylcholinesterase, (Na+,&amp;nbsp;K+)-, Mg2+-ATPase activities, antioxidant status, and learning performance of aged rats