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It is accepted that there is a genetic factor that influences the risk of suicidal behavior. The catechol-O-methyltransferase ( COMT ) gene, especially the Val108/158Met polymorphism, has been associated with suicide; however, no conclusive outcome has been attained. Therefore, the aim of the present study was to assess the role of COMT Val108/158Met in suicidal behavior throughout an updated meta-analysis.

The role of <em>COMT</em> gene Val108/158Met polymorphism in suicidal behavior: systematic review and updated meta-analysis