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Anterior visual pathway reflects axonal loss caused by both optic neuritis (ON) and neurodegeneration in multiple sclerosis (MS). Although the axonal injury post-ON is thought to be complete by 6 months of onset, most studies using optical coherence tomography (OCT) to evaluate retinal changes as a marker of neurodegeneration exclude eyes with a history of ON or consider them separately. The objective of this study was to assess whether the eyes post-ON (&gt;6 months) show in later years different rate of chronic retinal changes than the fellow eyes not affected by ON.

Do eyes with and without optic neuritis in multiple sclerosis age equally?