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Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic-pituitary-adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 ( CRHR1 ; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein ( CRHBP ; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI.

HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females