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Increasing evidence has indicated that dysfunction of miR-124 and target gene regulator of G protein signaling 4 ( RGS4 ) may be involved in the etiology and treatment of major depressive disorder (MDD). However, the molecular mechanisms are not fully understood. This study aimed to investigate whether common genetic variations in these two genes are associated with MDD and therapeutic response to antidepressants in the Chinese population.

neuropsychiatric disease and treatment

Analysis of the association of &lt;em&gt;MIR124-1&lt;/em&gt; and its target gene &lt;em&gt;RGS4&lt;/em&gt; polymorphisms with major depressive disorder and antidepressant response