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Cognitive dysfunction has been recognized as a cardinal feature of schizophrenia. Elucidating the neurobiological substrates of cognitive dysfunction in schizophrenia would help identify the underlying mechanism of this disorder. The rs1064395 single nucleotide polymorphism, within the gene encoding neurocan ( NCAN ), is reported to be associated with schizophrenia in European populations and may influence brain structure in patients with schizophrenia.

The <em>NCAN</em> gene: schizophrenia susceptibility and cognitive dysfunction