Open AccessThe dual-gate lumen model of renal monoamine transport
Author(s) -
Marty Hinz,
Thomas Uncini,
Alvin Stein
Publication year - 2010
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s11704
Subject(s) - medicine , monoamine neurotransmitter , lumen (anatomy) , dual (grammatical number) , pharmacology , serotonin , literature , art , receptor
The three-phase response of urinary serotonin and dopamine in subjects simultaneously taking amino acid precursors of serotonin and dopamine has been defined.1,2 No model exists regarding the renal etiology of the three-phase response. This writing outlines a model explaining the origin of the three-phase response of urinary serotonin and dopamine. A "dual-gate lumen transporter model" for the basolateral monoamine transporters of the kidneys is proposed as being the etiology of the three-phase urinary serotonin and dopamine responses.
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