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Acetaminophen (APAP) and ibuprofen (IBP) are two analgesic compounds with a long history of use. Both are considered safe at recommended over-the-counter daily doses. Chronic use, high doses, or concomitant medication can produce safety risks for both drugs. APAP is associated with increased risk of hepatic injury, while IBP can produce gastric bleeding and thromboembolic events. Using a combination of APAP and IBP provides superior analgesia without transgressing daily dose limits of each individual drug.

journal of pain research

&lt;p&gt;An integrated safety analysis of combined acetaminophen and ibuprofen (Maxigesic&lt;sup&gt;&amp;reg;&lt;/sup&gt;/ Combogesic&lt;sup&gt;&amp;reg;&lt;/sup&gt;) in adults&lt;/p&gt;