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Morbidity has been reported as a sequelae of crystalline steroid epidural steroid injections (ESIs), and particulate steroid size, aggregation, and embolization in brain and spinal cord may be the mechanism related to these neurologic effects.

journal of pain research

&lt;p&gt;Aggregation properties of triamcinolone acetonide injection in human serum: considerations when performing epidural steroid injections&lt;/p&gt;