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It was reported that epidural volume extension could decrease the ED 50 of intrathecal plain bupivacaine. In this study, we investigated the ED 50 of intrathecal hyperbaric ropivacaine followed by epidural normal saline bolus for cesarean section.

journal of pain research

ED&lt;sub&gt;50&lt;/sub&gt; of intrathecal ropivacaine for cesarean delivery with and without epidural volume extension with normal saline: a randomized controlled study.