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To demonstrate the antinociceptive and antihypersensitivity mechanisms of Cris-104 (1-{2-[5-(4-fluorophenyl)-1H-pyrazol-4-yl]ethyl}piperidine), a novel selective α 4 β 2 * nicotinic acetylcholine receptor (nAChR) agonist, in rodent acute/inflammatory and chronic pain models.

journal of pain research

Novel agonist of &amp;alpha;&lt;sub&gt;4&lt;/sub&gt;&amp;beta;&lt;sub&gt;2&lt;/sub&gt;* neuronal nicotinic receptor with antinociceptive efficacy in rodent models of acute and chronic pain