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Dexmedetomidine (DEX) could have an analgesic effect on pain transmission through the modulation of brain-derived neurotrophic factor (BDNF). In addition, KCC2-induced shift in neuronal Cl- homeostasis is crucial for postsynaptic inhibition mediated by GABAA receptors. Accumulating evidence shows that nerve injury, peripheral inflammation and stress activate the spinal BDNF/TrkB signal, which results in the downregulation of KCC2 transport and expression, eventually leads to GAGAergic disinhibition and hyperalgesia. The aim of this experiment was to explore the interaction between DEX and KCC2 at a molecular level in rats in the persistent postsurgical pain (PPSP).

journal of pain research

Dexmedetomidine attenuates persistent postsurgical pain by upregulating K<sup>+</sup>&ndash;Cl<sup>&minus;</sup>&nbsp;cotransporter-2 in the spinal dorsal horn in rats

Dexmedetomidine attenuates persistent postsurgical pain by upregulating K+–Cl− cotransporter-2 in the spinal dorsal horn in rats

Dexmedetomidine attenuates persistent postsurgical pain by upregulating K⁺–Cl⁻ cotransporter-2 in the spinal dorsal horn in rats