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Neuropathic pain is a debilitating condition that severely affects the quality of life for those with this pain condition, and treatment for pain relief is greatly sought-after. Zerumbone (Zer), a sesquiterpene compound isolated from the rhizomes of a Southeast Asian ginger plant, Zingiber zerumbet (L.) Roscoe ex Smith. (Zingiberaceae), showed antinociceptive and antiinflammatory properties when previously tested on models of nociception and inflammation.

journal of pain research

Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1&amp;beta;, IL-6, and TNF-&amp;alpha; in a mouse model of neuropathic pain