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Opioids are the most important pharmacological treatment for moderate-to-severe cancer pain, but side effects limit their use. Transdermal fentanyl (TDF) and oral prolonged-release oxycodone-naloxone (OXN-PR) are effective in controlling chronic pain, with less constipation compared to other opioids. However, TDF and OXN-PR have never been directly compared.

journal of pain research

A comparison between the administration of oral prolonged-release oxycodone-naloxonee and transdermal fentanyl in patients with moderate-to-severe cancer pain: a propensity score analysis