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Neuropathic pain resulting from peripheral nerve lesions is a common medical condition, but current analgesics are often insufficient. The identification of key molecules involved in pathological pain processing is a prerequisite for the development of new analgesic drugs. Hyperexcitability of nociceptive DRG-neurons due to regulation of voltage-gated ion-channels is generally assumed to contribute strongly to neuropathic pain. There is increasing evidence, that T-type Ca 2+ -currents and in particular the Ca v 3.2 T-type-channel isoform play an important role in neuropathic pain, but experimental results are contradicting.

journal of pain research

&lt;p&gt;Partial sciatic nerve ligation leads to an upregulation of Ni&lt;sup&gt;2+&lt;/sup&gt;-resistant T-type Ca&lt;sup&gt;2+&lt;/sup&gt; currents in capsaicin-responsive nociceptive dorsal root ganglion neurons&lt;/p&gt;