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During the last 15 years, gabapentin has become an established component of postoperative pain treatment. Gabapentin has been employed in a wide range of doses, but little is known about the optimal dose, providing the best balance between benefit and harm. This systematic review with meta-analyses aimed to explore the beneficial and harmful effects of various doses of gabapentin administered to surgical patients.

journal of pain research

Dose-related beneficial and harmful effects of gabapentin in postoperative pain management &amp;ndash; post hoc analyses from a systematic review with meta-analyses and trial sequential analyses