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Nonsteroidal anti-inflammatory drugs (NSAIDs) are metabolized by the cytochrome P450 enzymes (CYPs), predominantly CYP2C8 and CYP2C9. The aim of this study was to evaluate the possible association of polymorphisms in the CYP2C8*3 and CYP2C9 genes with the clinical efficacy of oral piroxicam (20 mg daily for 4 days) after lower third molar surgeries with regard to postoperative pain, swelling, trismus, adverse reactions, need for rescue medication and the volunteer's overall satisfaction.

journal of pain research

Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with &lt;em&gt;CYP2C8*3&lt;/em&gt; and &lt;em&gt;CYP2C9&lt;/em&gt;