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P2 receptors have been implicated in the release of neurotransmitter and pro-inflammatory cytokines due to their response to neuroexcitatory substances in the microglia. Dorsal horn P2Y 12 and P2Y 13 receptors are involved in the development of pain behavior induced by peripheral nerve injury. However, it is not known whether P2Y 12 and P2Y 13 receptors activation is associated with the expression and the release of interleukin-1B (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) in cultured dorsal spinal cord microglia. For this reason, we examined the effects of ADPβs (ADP analog) on the expression and the release of IL-1β, IL-6, and TNF-α.

journal of pain research

P2Y&lt;sub&gt;12 &lt;/sub&gt;and P2Y&lt;sub&gt;13&lt;/sub&gt; receptors involved in ADP&amp;beta;s induced the release of IL-1&amp;beta;, IL-6 and TNF-&amp;alpha; from cultured dorsal horn microglia