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Trypanosome infections still pose severe health and economic consequences, especially in the endemic regions of Sub-Saharan Africa. Trypanosome differentiation to the procyclic forms which lack the immune evasion mechanisms for survival in the bloodstream is prevented by tyrosine dephosphorylation which is catalyzed by protein-tyrosine phosphatase; thereby promoting survival of the parasites in the host. Inhibition of Protein-tyrosine phosphatase is a strategic therapeutic target that could attenuate trypanosomiasis. This study investigated the in vitro inhibitory effect of stem bark extracts of Khaya senegalensis and Tamarindus indica on the enzymatic activity of protein-tyrosine phosphatase.

journal of experimental pharmacology

&lt;p&gt;Inhibition of &lt;em&gt;Trypanosoma evansi&lt;/em&gt; Protein-Tyrosine Phosphatase by Myristic Acid Analogues Isolated from &lt;em&gt;Khaya senegalensis&lt;/em&gt; and Tamarindus &lt;em&gt;indica&lt;/em&gt;&lt;/p&gt;