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The outcome for chronic myelogenous leukemia (CML) patients presented in the chronic phase has changed dramatically since the introduction of tyrosine kinase inhibitor (TKI) therapy. Notably, an increased incidence of large granular lymphocytes (LGLs), which is related to immunological conditions, appears to be predictive of a favorable outcome for dasatinib therapy. We therefore examined the immunological characteristics of CML patients during dasatinib therapy by determining the plasma concentrations of five different biomarkers.

journal of blood medicine

Assessment of soluble cytotoxic T lymphocyte-associated antigen-4, transforming growth factor &amp;beta;&lt;sub&gt;1&lt;/sub&gt;, and&amp;nbsp;platelet-derived microparticles during dasatinib therapy for patients with chronic myelogenous leukemia