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Intractable pruritus in hemodialysis patients can significantly decrease their quality of life and is also associated with poor vital prognosis. Although combined multiple causes of intractable pruritus in these patients have been identified, no existing treatments are proven to be sufficiently effective. We conducted a post-marketing surveillance to follow-up and assess the safety and efficacy of nalfurafine, a selective κ-opioid receptor agonist, for the treatment of intractable pruritus in patients undergoing hemodialysis.

international journal of nephrology and renovascular disease

Post-marketing surveillance study of the safety and efficacy of nalfurafine hydrochloride (Remitch&lt;sup&gt;&amp;reg; &lt;/sup&gt;capsules 2.5 &amp;mu;g) in 3,762 hemodialysis patients with intractable pruritus