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Platinum-based chemotherapy (PBC) is a potent antineoplastic treatment, but cisplatin nephrotoxicity is often the limiting factor. Identifying the patients who are at risk for developing platinum-induced renal injury is an important issue. We tested urinary TIMP2·IGFBP7, a new US Food and Drug Administration (FDA)-cleared test to assess the risk of acute kidney injury (AKI), in a cohort of patients with malignant neoplastic disease receiving PBC.

Urinary TIMP2&middot;IGFBP7 for the prediction of platinum-induced acute renal injury

Urinary TIMP2·IGFBP7 for the prediction of platinum-induced acute renal injury