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Aortic valve disease is the most common valvular heart disease leading to valve replacement. The efficacy of pharmacological therapy for aortic valve disease is limited by the high mechanical stress at the aortic valves impairing the binding rate. We aimed to identify nanoparticle coating with entire platelet membranes to fully mimic their inherent multiple adhesive mechanisms and target the sclerotic aortic valve of apolipoprotein E-deficient (ApoE -/- ) mice based on their multiple sites binding capacity under high shear stress.

international journal of nanomedicine

&lt;p&gt;Platelet Membrane-Coated Nanoparticles Target Sclerotic Aortic Valves in ApoE&lt;sup&gt;−/−&lt;/sup&gt; Mice by Multiple Binding Mechanisms Under Pathological Shear Stress&lt;/p&gt;