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Polycation carriers show great foreground in the developing efficient and safe gene delivery; nevertheless, they are cytotoxic and unstable in vivo because of the excess cationic charge. PEGylation improves the biocompatibility and stability of polycation, whereas PEGylation restrains the endosomal escape to some extent.

<p>A versatile endosome acidity-induced sheddable gene delivery system: increased tumor targeting and enhanced transfection efficiency</p>