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Nanoparticles (NPs) are used in numerous products in technical fields and biomedicine; their potential adverse effects have to be considered in order to achieve safe applications. Besides their distribution in tissues, organs, and cellular localization, their impact and penetration during the process of tissue formation occurring in vivo during liver regeneration are critical steps for establishment of safe nanomaterials.

<p>Distribution of SiO<sub>2</sub>&nbsp;nanoparticles&nbsp;in 3D liver microtissues</p>

<p>Distribution of SiO<sub>2</sub> nanoparticles in 3D liver microtissues</p>