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Poly(lactic- co -glycolic acid) (PLGA) has emerged as a promising anticancer drug delivery scaffold. Camptothecin (CPT) has been fabricated into a variety of nanosized formulations to improve drug action. We report an experimental study on the effect of CPT-encapsulated PLGA (PLGA-CPT) nanoparticles (NPs) on drug-metabolizing cytochrome P450 enzyme, CYP3A4.

The impact of camptothecin-encapsulated poly(lactic-<em>co</em>-glycolic acid) nanoparticles on the activity of cytochrome P450 in vitro