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Selective internal radiation therapy (SIRT) is an effective treatment option for liver tumors, using Y-90-loaded polymer microspheres that are delivered via catheterization of the hepatic artery. Since Y-90 is a beta emitter and not conveniently imaged by standard clinical instrumentation, dosimetry is currently evaluated in each patient using a surrogate particle, 99m Technetium-labeled macroaggregated albumin ( 99m Tc-MAA). We report a new composite consisting of 99m Tc-labeled nanoparticles attached to the same polymer microspheres as used for SIRT, which can be imaged with standard SPECT.

international journal of nanomedicine

&lt;p&gt;&lt;sup&gt;99m&lt;/sup&gt;Tc-radiolabeled composites enabling in vivo imaging of arterial dispersal and retention of microspheres in the vascular network of rabbit lungs, liver, and liver tumors&lt;/p&gt;